Southampton's most recent spell in the Premier League has been quite disappointing and they still have a chance to finish at the bottom with one of the worst records in the history of the competition.
Tied on 11 points after playing 35 matches, it seems unlikely that the struggling Saints can earn another point to surpass the poor total achieved by Derby in the 2007-08 season.
The St Mary's team suffered a 2-0 defeat against fellow relegated team Leicester last week, and they have only managed to gather two points out of a possible 33 on their way down the league table.
Manchester City have also had a tough season, especially compared to their usual high standards, and their last hope of winning a trophy lies in the FA Cup.
A mid-season dip in form had a negative impact, but City have bounced back strongly and there is still a chance for them to claim the second spot from Arsenal in the upcoming weeks.
With just one defeat in their previous 12 matches, confidence has been restored at the Etihad, and the team has managed to keep five clean sheets in their last seven games.
Pep Guardiola's squad is focused on the FA Cup final later this month, but they are also on track to finish their league campaign in a positive manner.
Team news
Southampton's full-back Charlie Taylor is nursing an injury but might be involved in the upcoming matches, while Albert Gronbaek is unlikely to play again this season due to an Achilles problem.
Other than that, the Saints have a mostly fit squad after forward Paul Onuachu returned to action in the recent loss against Leicester.
Erling Haaland was on the bench in the win over Wolves and City's top scorer could make an appearance in the upcoming fixtures as he returns to full fitness.
Rodri and Nathan Ake have been in training, but they won't be rushed back with the FA Cup final looming. John Stones' comeback date is still uncertain.
The stats
City have only lost one of their last 12 matches across all competitions.
Southampton have suffered 28 league defeats so far this season.
The Citizens have kept clean sheets in five of their last seven games.
In three of the previous five encounters between these two teams, City have scored four goals.
City has only lost one of the last nine meetings with Southampton.
Prediction
Manchester City have shown glimpses of their former selves recently and they are likely to dominate against Southampton on Saturday.
With five clean sheets in their last seven fixtures, City should come out unharmed from St Mary's, especially considering that the home side seems to have lost their fighting spirit some time ago.
Even recently relegated Leicester achieved a 2-0 win against Southampton last week, and the struggling Saints, who have the lowest goal tally of 25 in the league at this stage, may find it hard to compete against their strong and in-form visitors.