- Real will host Atletico in a Madrid derby
- Bayer Leverkusen will travel to Bayern Munich in an all-German clash
- Premier League leaders Liverpool will face Paris Saint-Germain
As top clubs in Europe aim to secure a spot in the quarter-finals, we provide score predictions for the first-leg matches.
Club Brugge vs Aston Villa (Tuesday, 5.45pm)
Club Brugge, ranked 24th in the League Phase, caused an upset by beating Aston Villa at home in November. They are expected to put up a tough fight again, possibly leading to a tense second leg at Villa Park.
Score prediction: Club Brugge 1-1 Aston Villa
Borussia Dortmund vs Lille (Tuesday, 8pm)
Despite Lille's recent defeat to PSG, they have shown promise in the competition by defeating top teams like Real Madrid and Atletico Madrid. Dortmund, despite their lower standing in the Bundesliga, are likely to secure a win in the first leg.
Score prediction: Borussia Dortmund 2-1 Lille
PSV Eindhoven vs Arsenal (Tuesday, 8pm)
Both teams are going through a rough patch, with Arsenal struggling to score and PSV failing to keep clean sheets. Arsenal's quality should see them through this encounter.
Score prediction: PSV Eindhoven 1-2 Arsenal
Real Madrid vs Atletico Madrid (Tuesday, 8pm)
Recent Madrid derbies have been closely contested, with both teams evenly matched. Atletico comes into the match in better form, but Real will aim to secure a draw at home.
Score prediction: Real Madrid 1-1 Atletico Madrid
Feyenoord vs Inter (Wednesday, 5.45pm)
Inter, currently leading Serie A, are favored to win this encounter against Feyenoord, who eliminated AC Milan in the earlier rounds.
Score prediction: Feyenoord 0-1 Inter
Bayern Munich vs Bayer Leverkusen (Wednesday, 8pm)
Expect an exciting match between the top two German teams, who have had close encounters this season. Bayern will be motivated to take the lead into the second leg.
Score prediction: Bayern Munich 2-2 Bayer Leverkusen
Benfica vs Barcelona (Wednesday, 8pm)
Barcelona is expected to have the edge in this high-scoring encounter, having won their previous meeting. Both teams are in fine goal-scoring form.
Score prediction: Benfica 2-4 Barcelona
Paris Saint-Germain vs Liverpool (Wednesday, 8pm)
PSG's dominant form makes them favorites against Liverpool, who visit as Premier League leaders. The home side's attacking prowess could trouble Liverpool's defense.
Score prediction: Paris Saint-Germain 3-1 Liverpool