Cody Gakpo scored when he returned to PSV Eindhoven, but it wasn't enough to motivate a weakened Liverpool team as they lost their perfect Champions League record following a 3-2 defeat.
Coach Arne Slot opted to rest nine of the players who started on Saturday, looking ahead to the team's upcoming Premier League match against Bournemouth. However, Gakpo was given the chance to play against his former club.
He scored a penalty in the 28th minute, seemingly coming back to haunt his childhood team where he had played for five seasons before moving to Anfield two years ago.
PSV took advantage of their opponents' weaknesses and despite Harvey Elliott also scoring, goals from Johan Bakayoko, Ismael Saibari, and Ricardo Pepi led to Liverpool's third loss of the season, marking their 100th defeat in European football.
Liverpool's young player Amara Nallo received a red card on his debut, just three minutes into the game.
With several key players absent, including Mohamed Salah, Virgil van Dijk, and others, Slot had to rely on a less experienced squad.
Unfortunately, Darwin Nunez had to withdraw due to illness, resulting in Jayden Danns making his first start and Champions League debut at the age of 19 years and 13 days, becoming the youngest player to start for the club in the competition.
Despite the challenges, Federico Chiesa made his first start since September and played a key role in Gakpo's goal by earning a penalty after being fouled by Joey Veerman.
Elliott initially scored, but the goal was disallowed, allowing Gakpo to convert the penalty. PSV later equalized, and in the fourth minute of added time, secured their first victory over Liverpool.
With limited resources, the second half was about minimizing the damage, as Gakpo and Robertson were substituted early on. A last-minute challenge by Morton prevented further goals by the opposition.
Debutant Nallo's game ended on a disappointing note as he was sent off shortly after coming on, following a foul on Bakayoko.