A week following Rangers' determined 0-0 draw against Athletic Bilbao at Ibrox, the teams will face off once more at San Mames to secure a spot in the Europa League semi-finals for this season.
The Spanish team is fueled by the prospect of potentially reaching the tournament final in May, which will be hosted at their home stadium.
Team updates
Yuri Berchiche, the left-back, is close to returning from a calf injury, but he is unlikely to start against Athletic, as Lekue Martinez has been performing well in his absence.
Ghanaian player Inaki Williams is uncertain for the match after sustaining an injury during Sunday's 3-1 victory over Rayo Vallecano.
Rangers will be missing Robin Propper due to suspension following his red card in the first leg. John Souttar, who is back from a ban, is expected to fill in the gap in Barry Ferguson's defensive trio.
Nicolas Raskin, Tom Lawrence, Ridvan Yilmaz, Vaclav Cerny, and Bailey Rice are all questionable for the upcoming game.
Match statistics
Athletic has managed to keep clean sheets in four of their last five matches.
The Basque team remains unbeaten at home in La Liga and the Europa League since their 2-0 defeat to Atletico Madrid in August. They have triumphed in all five of their Europa League home matches.
Rangers are currently on a three-game winless streak and have failed to score in their last two Europa League encounters.
As for corner kicks, Bilbao has been awarded 62 corners in their 11 Europa League games, which is 21 more than Rangers have received in the same number of matches.
Prediction
Rangers narrowly escaped with a draw at Ibrox last week, playing with 10 men for a significant period to hold Bilbao to a goalless result.
Despite dominating the game, creating opportunities, and even missing a penalty, the visitors were regretful for not converting their chances against the resilient Scots.
Now, Rangers must face the Basque team again, this time with a full 11-man squad, at the San Mames stadium where Athletic has not suffered a significant defeat since August.
Ernesto Valverde's La Liga side currently holds the fourth position and is not far behind the top three teams, making them the toughest opponents Rangers have encountered so far.
It seems unlikely that Barry Ferguson's team could rely on luck for a second consecutive match.
Similar to the pressure exerted by the Spanish team in Glasgow last week, the hosts are expected to control the game in Bilbao, creating opportunities and possibly winning several corners.
In the first leg, they secured nine corners, averaging nearly six per game throughout the tournament, and are likely to exceed 7.5 corners in Thursday's match.