Craig Bellamy is off to a good start as Wales manager, with his team now undefeated in seven matches after beating Kazakhstan 3-1 in Cardiff.
In Group J, North Macedonia also had a strong start by defeating Liechtenstein 3-0 in the Alps on Saturday.
The top team in the group, Belgium, has yet to begin their campaign. A victory in Skopje would provide Wales with a solid foundation as they aim to qualify for next summer's tournament in North America.
Team news
Against Kazakhstan, Wales was missing Aaron Ramsey, Harry Wilson, and Wes Burns, and they will continue to be absent on Monday.
Sorba Thomas, Daniel James, and David Brooks were in the starting lineup, while Rabbi Matondo came off the bench to score his first international goal.
Bojan Miovski and Aleksandar Trajkovski led the attack for North Macedonia in their win over Liechtenstein, with both players scoring goals.
Enis Bardhi and Eljif Elmas will be crucial midfielders for North Macedonia.
The statistics
Craig Bellamy has not lost any of his seven games as Wales manager, including guiding the team to promotion in the UEFA Nations League last year.
In the previous encounters between these teams, each has secured a victory when playing away from home in the road to the Brazil 2014 World Cup.
North Macedonia has won their last six matches under manager Blagoja Milevski.
Goalkeeper Stole Dimitrievski set a new national record for North Macedonia by keeping six consecutive clean sheets.
Bojan Miovski has been directly involved in six goals in six games for North Macedonia.
North Macedonia has only seen both teams score in one of their last eight World Cup qualifiers.
Prediction
Wales qualified for the Qatar 2022 World Cup after a 64-year absence and Bellamy believes they can make it to the next tournament, especially with more qualification spots available. "I'm excited to work with the group. We're all just looking forward to it. I genuinely feel this is a group we want to go and win," said Bellamy ahead of this Group J match.
Belgium is the team to challenge for the top spot, but Wales aims to secure six points before Belgium starts their campaign.
Wales will need to pay attention to former Aberdeen striker Miovski, but with strong attacking options like Brennan Johnson, James, and Brooks, they have their own threats to pose.
North Macedonia's winning streak is a warning for Wales, but they haven't defeated a team ranked higher than 100th during this run.
Bellamy has Wales playing well, and with better defensive decisions, they could have comfortably beaten Kazakhstan. They are capable of securing a win in Skopje.