- Crystal Palace have recorded six clean sheets in their most recent nine games
- Newcastle have seen at least three goals in nine of their last 10 matches at home
- Fulham have emerged victorious in five out of their last six games on the road
We have now entered the last-16 phase of the FA Cup, and after Plymouth, a team from the Championship, caused an upset by eliminating the Premier League leaders Liverpool, their next challenge is an arduous visit to Manchester City.
Other Championship teams facing top-tier opponents away from home are Millwall, who will be against their London counterparts Crystal Palace, and Cardiff, who are set to play against Aston Villa on Friday evening.
Here are our predictions for the final scores of all eight FA Cup fifth-round matches happening this weekend.
Aston Villa vs Cardiff (Friday, 8pm)
Aston Villa's superior quality is likely to secure them a win in this match, despite needing to bounce back from their 4-1 defeat to Crystal Palace on Tuesday.
In seven out of Villa's last eight home victories, both teams have scored, giving Cardiff some hope of finding the net, although not much is expected from the Bluebirds.
Score prediction: Aston Villa 3-1 Cardiff
Crystal Palace vs Millwall (Saturday, 12.15pm)
Millwall secured an impressive victory against the leaders Leeds in the previous round, but Crystal Palace poses a more challenging task.
Crystal Palace comes into this fixture following a 4-1 win against Aston Villa and have only conceded in three of their last nine matches.
Score prediction: Crystal Palace 2-0 Millwall
Preston vs Burnley (Saturday, 12.15pm)
Burnley have won four of their last five matches without conceding a goal, and this local derby might not see much action in terms of goals.
Burnley and Preston have played out two goalless draws in the Championship this season, suggesting a high likelihood of no goals in regular time at Deepdale.
Score prediction: Preston 0-0 Burnley
Bournemouth vs Wolves (Saturday, 3pm)
Just a week ago, Wolves secured a 1-0 victory against Bournemouth in the Premier League, and they could repeat this result as they strive to secure European football through their league position.
Score prediction: Bournemouth 1-2 Wolves
Manchester City vs Plymouth (Saturday, 5.45pm)
Manchester City has scored at least two goals in six out of their seven cup and Champions League games at home this season and are likely to dominate against Plymouth, who surprised everyone by defeating a weakened Liverpool side.
The FA Cup remains Manchester City's last chance for silverware this season, and they are expected to capitalize on facing Plymouth, who have one of the leakiest defences in the Championship.
Score prediction: Manchester City 4-0 Plymouth
Newcastle vs Brighton (Sunday, 1.45pm)
This match might see a high number of goals, and it could potentially require extra time to determine the winner. Newcastle has witnessed at least three goals in nine of their last ten home games, while Brighton has been potent on the road, scoring 18 goals in their recent eight away matches.
Score prediction: Newcastle 2-2 Brighton
Manchester United vs Fulham (Sunday, 4.30pm)
Manchester United has failed to keep a clean sheet in their last nine home games and could face a surprise when Fulham travels to Old Trafford.
Fulham has triumphed in five of their last six away games and could secure a spot in the quarter-finals with a notable victory.
Score prediction: Manchester United 1-2 Fulham
Nottingham Forest vs Ipswich (Monday, 7.30pm)
Nottingham Forest has been unsuccessful in their last four matches and required a penalty shootout to advance past League One's Exeter in the previous round. Nevertheless, they are still expected to have the upper hand against Ipswich, who have struggled to match Premier League standards this season.
Score prediction: Nottingham Forest 3-0 Ipswich.