- Preston, the team with the lowest rank still in the competition, will face Aston Villa
- Manchester City will visit Bournemouth
- Fulham will welcome Crystal Palace, their rivals from London
The FA Cup quarter-finals will be the main focus this weekend as teams compete for a spot in the semi-finals and a chance to play at Wembley.
Out of the eight teams remaining in the tournament, seven are from the Premier League. Bournemouth, Brighton, Crystal Palace, and Fulham have never won the FA Cup before.
Preston North End, who last reached the quarter-finals in 1966, are the representatives from the Championship.
This weekend promises exciting FA Cup action as we make predictions for all four matches.
Fulham vs Crystal Palace (Saturday, 12.15pm)
London rivals Fulham and Crystal Palace will clash in a closely-contested quarter-final at Craven Cottage as they both aim for their first FA Cup victory.
Crystal Palace have been in excellent form with four consecutive wins and will be a tough challenge for Marco Silva's team. However, Fulham is predicted to advance on penalties, similar to their previous victory over Manchester United, after a tense 120 minutes.
Score prediction: Fulham 1-1 Crystal Palace (Fulham to win on penalties)
Brighton vs Nottingham Forest (Saturday, 5.15pm)
After suffering a 7-0 defeat to Nottingham Forest in February, Brighton went on a seven-game unbeaten streak, winning six of those matches.
Following impressive wins against Newcastle and Chelsea in the FA Cup, Brighton is expected to secure a spot in the semi-finals at the expense of Nottingham Forest.
Score prediction: Brighton 3-1 Nottingham Forest
Preston North End vs Aston Villa (Sunday, 1.30pm)
Preston, the only team from outside the Premier League still in contention, are likely to face a tough challenge from Aston Villa as they aim to reach the semi-finals for the first time in 61 years.
Aston Villa, under the leadership of Unai Emery, have been in good form, winning three of their last four games without conceding a goal. They are also competing for a top-four finish in the league and have a crucial Champions League quarter-final against Paris Saint-Germain on the horizon.
Score prediction: Preston North End 0-2 Aston Villa
Bournemouth vs Manchester City (Sunday, 4.30pm)
Despite a challenging season, Manchester City have the opportunity to end on a high note by clinching the FA Cup title. The seven-time champions are expected to avenge their Premier League loss to Bournemouth earlier in the season and secure a place in the semi-finals.
Bournemouth, who only managed one win in their last five matches, will face a strong City side that is determined to succeed despite recent setbacks against Nottingham Forest and Brighton.
Score prediction: Bournemouth 1-2 Manchester City