These two sides had lofty ambitions at the start of the season, with Luton looking to bounce back to the Premier League at the first time of asking, while Hull spent big in the summer looking to lift themselves into the promotion picture.
However, it has not worked out well for either team who find themselves in the lower region of the second tier after picking up just seven wins between after 15 rounds of action.
Hull are slightly better off in 19th place, but are ahead of the 21st-placed Hatters only on goal difference.
Town are warm favourites to win this contest on home turf and it could be another miserable away day for the toothless Tigers.
Team news
Alfie Doughty should return after missing Luton's 5-1 hammering at Middlesbrough, but Reece Burke, Mads Andersen and Reuell Walters look likely to remain on sidelines for the Hatters.
For the visitors Ryan Longman and Dogukan Sinik are pushing to return from long-term injuries, but Abu Kamara is unlikely to feature after missing the two matches prior to the recent international break.
Liam Millar and Moham Belloumi have been ruled out for the remainder of the season with ACL injuries.
The stats
Luton have lost one of their last six home league fixtures.
One or both teams have failed to score in 11 of the last 14 meetings between these two sides.
Hull have scored just four goals across their last seven matches and are winless in that time.
Luton are unbeaten in their last five meetings with Hull.
Prediction
This match has been dubbed as El Sackico in some quarters of the media, with Luton boss Rob Edwards and his opposite number Tim Walter both said to be on thin ice following poor starts to the season.
Despite ambitions of a promotion charge, Luton and Hull have slipped down into the bottom six of the Championship, with both teams finding wins and goals hard to come by.
One glimmer of hope has been Luton's home form and that is why they are a tentative fancy to win this contest, along with their strong record against City.
The Hatters have lost just one of their last six league matches at Kenilworth Road and are unbeaten in five matches against the Tigers.
Four of those were wins, while they conceded just once, so they look a decent bet to win this match 2-0.
The Tigers have scored just four goals across their last seven matches and one or both teams have failed to score 11 of the last 14 meetings between these two.
Should Luton edge in front, there is a good chance they pick up a second goal as the visitors push forward in search of a response.