Chelsea have been defeated in just two out of their 18 Premier League matches at Stamford Bridge this season and are widely expected to finish their home campaign with a win against Manchester United.
The Blues are still in the running for a spot in the Champions League and are gearing up for the Conference League final against Real Betis.
United supporters are eagerly anticipating the Europa League final showdown with Tottenham, but the Red Devils find themselves in 16th place in the table and are on course for their lowest league finish since their relegation in 1974.
Team news
Chelsea will be without striker Nicolas Jackson due to suspension, while fellow forwards Christopher Nkunku and Marc Guiu are sidelined with injuries.
United's loanee Jadon Sancho is ineligible to play against his parent club, and Wesley Fofana, Omari Kellyman, Aaron Anselmino, and Mykhailo Mudryk are unavailable.
There is a doubt over United defender Leny Yoro (ankle) being able to play. Matthijs de Ligt, Lisandro Martinez, Joshua Zirkzee, Diogo Dalot, Toby Collyer, and Ayden Heaven are all injured.
The stats
Chelsea have emerged victorious in five of their last six matches across all competitions.
The Blues have secured five of their last eight home games with a 1-0 scoreline.
Chelsea have only suffered two defeats in their 18 league fixtures at Stamford Bridge this season.
United have lost five out of their last seven Premier League games.
The Red Devils have failed to score in 11 of their 17 league losses this season.
United's lone victories in their last 13 league matches came against relegated Ipswich and Leicester.
Prediction
United's struggles in the Premier League persisted with a 2-0 loss at home to West Ham last time out, and it seems unlikely they will reverse their fortunes at Chelsea on Friday.
The Europa League final is the primary focus for manager Ruben Amorim, who is anticipated to rest key players at Stamford Bridge.
While Chelsea have their sights set on European success in the Conference League, they remain highly motivated in the Premier League.
A triumph over United would draw them level on points with third-placed Newcastle, who face Arsenal this weekend, making Enzo Maresca's side a solid choice to win without conceding.
The Blues have clinched victory and kept a clean sheet in six of their last nine home games in all competitions, notably securing 1-0 wins over Leicester, Tottenham, and Everton.
Maresca faces challenges in attack with Nicolas Jackson suspended, Christopher Nkunku injured, and United loanee Jadon Sancho ineligible.
Nevertheless, key player Cole Palmer showcased top form in the 3-1 triumph over champions Liverpool earlier this month, and the home defense has little to fear from United's attackers.
The Red Devils suffered a 4-3 defeat at Brentford in their most recent away league outing, failing to score in four of their last seven top-flight matches.
United's sole victories in the league since February have come against relegated Ipswich and Leicester, indicating another frustrating encounter may be on the cards against Champions League-chasing Chelsea.