Two teams who have not managed to secure a victory in their past five matches will face off at the London Stadium, with West Ham looking to break their winless streak against bottom-placed Southampton.
The Hammers put up a good fight against leaders Liverpool in their last game at Anfield and will aim for a third consecutive victory over the Saints.
Southampton have already been relegated and it seems likely that some players will not remain at St Mary’s next season. Their only motivation now is to surpass Derby's record-low points tally of 11.
Team news
Despite requiring a pain-relieving injection in his toe, Aaron Wan-Bissaka is set to be fit for Saturday's match according to Graham Potter.
Crysencio Summerville is still sidelined and Potter mentioned that his return is still "a few weeks" away. Michail Antonio remains unavailable and Potter is cautious about managing Niclas Fullkrug's game time due to a hamstring issue.
Interim Southampton manager Simon Rusk has disclosed that striker Paul Onuachu faces a 50-50 chance and will undergo a fitness assessment on Friday. Flynn Downes is back from suspension and there is a possibility of youngster Jay Robinson making another appearance following his debut against Aston Villa.
The stats
West Ham have garnered four points from their last three matches at the London Stadium.
The Hammers have defeated Leicester and Ipswich, the other teams in the relegation zone, at home.
All four of West Ham's recent goals have been scored in the second half.
Southampton have only won one of their 16 away games in the league this season, suffering 13 defeats.
The Saints have only managed one victory in their last 12 encounters with West Ham.
Prediction
It seems improbable for Southampton to come away with points from their upcoming trip to the capital, particularly with West Ham displaying signs of progress under Potter.
Following a 2-2 draw against Bournemouth at home, West Ham appeared on course for a point at Liverpool until a late goal from Virgil van Dijk handed the win to the league leaders.
Saints have only obtained one point from their last eight league games and have scored a mere five goals during that period.
They have failed to score in their recent two clashes with West Ham, one of which resulted in a 1-0 loss at St Mary’s on Boxing Day.
Jarrod Bowen secured the winning goal that day and also found the net in West Ham's previous home match.
It is notable that West Ham's last four goals have been netted in the second half of games, while nine of the last 12 goals conceded by Southampton have come after the interval.
West Ham emerged victorious in the earlier encounter on Boxing Day with a 1-0 win, thanks to Bowen's decisive goal in the 59th minute.